| Country: | MEX |
| Type: | FH |
| Route: | 54D |
| Alternate Name: | Autopista Guadalajara-Colima |
| Maint: | Operadora de Autopistas Sayula |
| Length Km: | 148 |
| Length Ref: | [1] |
| Established: | January 1989 |
| Direction A: | South |
| Direction B: | North |
| Terminus A: | in Colima, Colima |
| Terminus B: | near Acatlán de Juárez, Jalisco |
Federal Highway 54D (Autopista Guadalajara-Colima) is a toll highway connecting Colima, Colima to Acatlán de Juárez, Jalisco. The road is operated by Operadora de Autopistas Sayula, which charges cars 272 pesos to travel Highway 54D.[2]
Highway 54D begins at an interchange with Highways 80 and 15 in Acatlán de Juárez, some 35km (22miles) southwest of Guadalajara. The road proceeds south and southwest through Zacoalco de Torres, Sayula, Ciudad Guzmán and Atenquique in Jalisco, as well as Cuauhtémoc in Colima, before ending northeast of Colima city. In total, it has seven interchanges.