| Country: | MEX |
| Type: | FH |
| Route: | 53 |
| Maint: | SCT |
| Length Km: | 521.61 |
| Length Ref: | [1] [2] |
| Length Notes: | Length includes 115.71km (71.9miles) concurrent with Fed. 57 |
| Length Round: | 2 |
| Direction A: | South |
| Terminus A: | near Apodaca, N.L. |
| Junction: | in General Escobedo near Castaños, Coah. in Monclova in Nueva Rosita |
| Direction B: | North |
| Terminus B: | Boquillas del Carmen near Mexico – United States border |
| States: | Nuevo León, Coahuila |
| Previous Type: | FH |
| Previous Route: | 52 |
| Next Type: | FH |
| Next Route: | 54 |
Federal Highway 53 (Carretera Federal 53) (Fed. 53) is part of the free (libre) part of the federal highways corridors (los corredores carreteros federales) of Mexico, and connects metropolitan Monterrey, Nuevo León to Boquillas del Carmen, Coahuila near the Mexico–United States border.[2]
|-|N.L.|115.90[1] |72.02|-|Coah.|405.71[2] |252.10|-|Total|521.61|324.11|}
The northern terminus is at Boquillas del Carmen near the Mexico–United States border along the Rio Grande.