| Country: | MEX |
| Type: | FH |
| Route: | 45 |
| Maint: | Secretariat of Communications and Transportation |
| Length Km: | 1491.73 |
| Length Round: | 2 |
| Length Ref: | [1] [2] [3] [4] [5] |
| Direction B: | North |
| Terminus B: | at the Mexico–US border at El Paso, TX, United States |
| Junction: | Fed. 85 in Portezuelo Fed. 57 in Puerta de Palmillas Fed. 120 in San Juan del Río Fed. 71 in San Francisco de los Romo Fed. 49 in Troncoso, Las Palmas y Jiménez Fed. 54 in Zacatecas Fed. 40 in Durango Fed. 23 in Durango Fed. 34 in Conejo Fed. 24 in Hidalgo del Parral Fed. 16 in Chihuahua City Fed. 10 in El Sueco Fed. 2 in Ciudad Juárez |
| Direction A: | South |
| Previous Type: | FH |
| Previous Route: | 44 |
| Next Type: | FH |
| Next Route: | 49 |
Federal Highway 45 (La Carretera Federal 45) (Fed. 45) is the free (libre) part of the federal highways corridors (los corredores carreteros federales), and connects Ciudad Juárez, Chihuahua through the Chihuahuan Desert to Panales, Hidalgo.[6]
It is operated under the management of the Secretariat of Communications and Transportation. Custody is the responsibility of the National Guard (GN). Fed. 45 is part of the Pan-American Highway. Federal Highway 45D is the tolled part of the route; in some areas the two run in parallel with the tolled section being faster.
The cities that are connected from north to south are Ciudad Juárez, Chihuahua City, Durango City, Zacatecas City, San Francisco de los Romo, Aguascalientes City, León, Guanajuato, Irapuato, Celaya, Guanajuato, Salamanca, Guanajuato, Querétaro City, Portezuelo, and Panales.