| Country: | MEX |
| Type: | FH |
| Route: | 125 |
| Maint: | Secretariat of Communications and Transportation |
| Length Km: | 494.9 |
| Section1: | North segment |
| Length Km1: | 107.5 |
| Length Ref1: | [1] |
| Direction A1: | North |
| Terminus A1: | in Conejos |
| Direction B1: | South |
| Terminus B1: | in Fortín de las Flores |
| Section2: | Middle segment |
| Length Km2: | 119.4 |
| Length Ref2: | [2] |
| Direction A2: | North |
| Terminus A2: | in Tehuacán |
| Direction B2: | South |
| Terminus B2: | in Huajuapan de León |
| Section3: | South segment |
| Length Km3: | 268 |
| Length Ref3: | [3] |
| Direction A3: | North |
| Terminus A3: | in Yucudaa |
| Direction B3: | South |
| Terminus B3: | in Pinotepa Nacional |
| Previous Type: | FH |
| Previous Route: | 123 |
| Next Type: | FH |
| Next Route: | 126 |
Federal Highway 125 (Carretera Federal No. 125) is a Federal Highway of Mexico that runs from Veracruz south across the Sierra Madre Oriental to just north of the Pacific Ocean in Oaxaca. Federal Highway 125 is split into three segments: the first segment travels from Conejos, Veracruz in the north to Fortín de las Flores in the south. The second segment travels from Tehuacán, Puebla in the north to Huajuapan de León, Oaxaca in the south. The third segment travels from Yucudaa, Oaxaca to Pinotepa Nacional, Oaxaca.