Mexedrone Explained

Mexedrone (also known as 4-MMC-MeO) is a stimulant and an entactogen drug of the cathinone class that has been sold online as a designer drug.[1] [2] [3] [4] It is the alpha-methoxy derivative of Mephedrone.

Pharmacology

Mexedrone acts as a weak serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 5289 nM, 8869 nM and 6844 nM, respectively, as well as a weak serotonin releasing agent (SRA) with an EC50 value of 2525 nM.[5]

Legal status

Mexedrone is illegal in Sweden as of January 26, 2016[6] as well as Japan as of August 24, 2016.[7]

See also

Notes and References

  1. Web site: Mexedrone. New Synthetic Drug Database.
  2. Qian Z, Jia W, Li T, Liu C, Hua Z . Identification and analytical characterization of four synthetic cathinone derivatives iso-4-BMC, β-TH-naphyrone, mexedrone, and 4-MDMC . Drug Testing and Analysis . 9 . 2 . 274–281 . February 2017 . 27352812 . 10.1002/dta.1983 .
  3. Kuś P, Rojkiewicz M, Kusz J, Książek M, Sochanik A . Spectroscopic characterization and crystal structures of four hydrochloride cathinones: N-ethyl-2-amino-1-phenylhexan-1-one (hexen, NEH), N-methyl-2-amino-1-(4-methylphenyl)-3-methoxypropan-1-one (mexedrone), N-ethyl-2-amino-1-(3,4-methylenedioxyphenyl)pentan-1-one (ephylone) and N-butyl-2-amino-1-(4-chlorophenyl)propan-1-one (4-chlorobutylcathinone) . Forensic Toxicology . 37 . 2 . 456–464 . 14 May 2019 . 10.1007/s11419-019-00477-y . free . 20.500.12128/9638 . free .
  4. Roberts L, Ford L, Patel N, Vale JA, Bradberry SM . 11 analytically confirmed cases of mexedrone use among polydrug users . Clinical Toxicology . 55 . 3 . 181–186 . March 2017 . 28075189 . 10.1080/15563650.2016.1271424 . 33220365 .
  5. McLaughlin G, Morris N, Kavanagh PV, Power JD, Dowling G, Twamley B, O'Brien J, Talbot B, Walther D, Partilla JS, Baumann MH, Brandt SD . 6 . Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone . Drug Testing and Analysis . 9 . 3 . 358–368 . March 2017 . 27524685 . 5336524 . 10.1002/dta.2053 .
  6. Web site: 31 nya ämnen kan klassas som narkotika eller hälsofarlig vara . Folkhälsomyndigheten . sv. November 2015.
  7. Web site: 指定薬物一覧 . Ministry of Health, Labour and Welfare . Japanese.

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