Methylprednisolone suleptanate explained

Methylprednisolone suleptanate, sold under the brand names Medrosol and Promedrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically, the C21 suleptanate 21-(8-(methyl-(2-sulfoethyl)amino)-1,8-dioxooctanoate) ester of methylprednisolone.^{[1] [2]} It acts as a prodrug of methylprednisolone.^[3] Methylprednisolone suleptanate was developed as an improved alternative to methylprednisolone acetate (Depo-Medrol) with greater water solubility for use by intravenous administration.

See also

• List of corticosteroid esters § Methylprednisolone esters

External links

• Methylprednisolone suleptanate - AdisInsight

Notes and References

1. Book: J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 811–.
2. Book: Index Nominum 2000: International Drug Directory. 2000. Taylor & Francis. 978-3-88763-075-1. 675–.
3. Ferry JJ, Della-Coletta AA, Weber DJ, VanderLugt JT . Pilot study of the pharmacokinetics of methylprednisolone after single and multiple intravenous doses of methylprednisolone sodium succinate and methylprednisolone suleptanate to healthy volunteers . J Clin Pharmacol . 34 . 11 . 1109–15 . November 1994 . 7876403 . 10.1002/j.1552-4604.1994.tb01988.x . 40533592 .