Methylprednisolone acetate explained

Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical and veterinary medicine.^{[1] [2] [3] [4] [5] [6] [7]} It has been formulated as an aqueous suspension for intramuscular, intra-articular, soft tissue, and intralesional injection alone and in combination with lidocaine, a local anesthetic. Methylprednisolone acetate was previously suspended with polyethylene glycol but is no longer formulated with this excipient due to concerns about possible toxicity.^[8] Depo methylprednisolone acetate is a depot injection and is absorbed slowly with a duration of weeks to months with a single intramuscular injection.

See also

• List of corticosteroid esters § Methylprednisolone esters

Notes and References

1. Web site: Depo-Medrol- methylprednisolone acetate injection, suspension . DailyMed . 18 January 2019 . 19 February 2020.
2. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 811–.
3. Book: Index Nominum 2000: International Drug Directory. 2000. Taylor & Francis. 978-3-88763-075-1. 675–.
4. Book: Muller NF, Dessing RP . European Drug Index: European Drug Registrations . Fourth . 19 June 1998. CRC Press. 978-3-7692-2114-5. 337–.
5. Book: Plumb DC . Plumb's Veterinary Drug Handbook: Pocket. 21 February 2018. John Wiley & Sons. 978-1-119-34649-4. 1088–1091.
6. Book: Lennard TA, Vivian DG, Walkowski, Singla AK . Pain Procedures in Clinical Practice E-Book. 11 June 2011. Elsevier Health Sciences. 978-1-4377-3774-5. 8–.
7. Book: Scott DW, Miller Jr WH . Equine Dermatology - E-Book. 1 December 2010. Elsevier Health Sciences. 978-1-4377-0921-6. 122–.
8. Book: Canale ST, Beaty JH . Campbell's Operative Orthopaedics E-Book. 29 October 2012. Elsevier Health Sciences. 978-0-323-08718-6. 1906–.