Methylornithine synthase explained

Methylornithine synthase
Ec Number:	5.4.99.58

Methylornithine synthase (PylB) is an enzyme with systematic name L-lysine carboxy-aminomethylmutase.^{[1] [2]} This enzyme catalyses the conversion of L-lysine into (3R)-3-methyl-D-ornithine.

The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical enzymes.

Notes and References

1. Gaston MA, Zhang L, Green-Church KB, Krzycki JA . The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine . Nature . 471 . 7340 . 647–50 . March 2011 . 21455182 . 3070376 . 10.1038/nature09918 . 2011Natur.471..647G .
2. Quitterer F, List A, Eisenreich W, Bacher A, Groll M . Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis . Angewandte Chemie . 51 . 6 . 1339–42 . February 2012 . 22095926 . 10.1002/anie.201106765 .