Methylamine—glutamate N-methyltransferase explained

Methylamine-glutamate N-methyltransferase
Ec Number:	2.1.1.21
Cas Number:	9045-32-3
Go Code:	0047148

In enzymology, a methylamine-glutamate N-methyltransferase is an enzyme that catalyzes the chemical reaction

methylamine + -glutamate

\rightleftharpoons NH₃ + N-methyl--glutamate

Thus, the two substrates of this enzyme are methylamine and -glutamate, whereas its two products are NH₃ and N-methyl--glutamate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methylamine:-glutamate N-methyltransferase. Other names in common use include N-methylglutamate synthase, and methylamine-glutamate methyltransferase. This enzyme participates in methane metabolism.

References

• Shaw WV, Tsai L, Stadtman ER . 1966 . The enzymatic synthesis of N-methylglutamic acid . J. Biol. Chem. . 241 . 935 - 45 . 5905132 . 4 .