Methyl 2-bromoacetate explained

Methyl 2-bromoacetate (methyl bromoactate) is a chemical compound with the molecular formula C3H5BrO2.

Properties

Methyl 2-bromoacetate is colorless or straw-colored liquid. The smell is sharp and penetrating. It is soluble in water and also has a higher density than water.[1] It is incompatible with acids, bases, oxidizing agents, and reducing agents.

Application

Methyl bromoacetate is an alkylating agent. It has been used to alkylate phenol and amino groups.[2] [3] Moreover, it can be used to make vitamins and pharmaceutical drugs. It is commonly used as a reagent in chemical modification of histidine.[1] In addition, methyl bromoacetate also use in synthesize of coumarins and cis-cyclopropane. It reacts with conjugated base and produce alkylated carbene complexes.[4]

Safety

Methyl bromoacetate can be toxic by ingestion and inhalation. It can also irritate the skin and eyes.[1]

See also

References

  1. Web site: Methyl Bromoacetate - Compound Summary for CID 60984 . PubChem Compound Database. National Center for Biotechnology Information. 9 July 2017. USA. Identification.
  2. Piątek. Piotr. Jurczak. Janusz. A selective colorimetric anion sensor based on an amide group containing macrocycle†. The Royal Society of Chemistry. 25 September 2002. 12430485 .
  3. Raju. B.. Murphy. E.. Levy. L.A.. Hall. R.D.. London. R.E.. A fluorescent indicator for measuring cytosolic free magnesium. The American Journal of Physiology. 256. 3 Pt 1. C540-8. 1 March 1989 . 2923192. 10.1152/ajpcell.1989.256.3.C540.
  4. Web site: A10605 Methyl bromoacetate, 98+%. Alfa Aesar. 9 July 2017.

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