Methoxetamine Explained

Verifiedfields:changed
Watchedfields:changed
Verifiedrevid:451563566
Iupac Name:(R/S)-2-(3-Methoxyphenyl)-2-(ethylamino)cyclohexanone[1]
Width:125px
Width2:200px
Legal Br:F2
Legal Br Comment:[2]
Legal Uk:Class B
Legal Us:Schedule I (as of July 6, 2022)[3]
Legal De:Anlage I
Legal Un:P II
Legal Un Comment:[4]
Addiction Liability:High[5]
Class:NMDA receptor antagonists
Dissociative hallucinogens; General anesthetics
Elimination Half-Life:3–6 hours
Cas Number:1239943-76-0
Atc Prefix:None
Kegg:C22711
Chemspiderid:24721792
Pubchem:52911279
Unii:ZO5ZCE6E12
Synonyms:MXE; 3-MeO-2'-oxo-
C:15
H:21
N:1
O:2
Smiles:O=C1CCCCC1(C2=CC=CC(OC)=C2)NCC
Stdinchi:1S/C15H21NO2/c1-3-16-15(10-5-4-9-14(15)17)12-7-6-8-13(11-12)18-2/h6-8,11,16H,3-5,9-10H2,1-2H3
Stdinchikey:LPKTWLVEGBNOOX-UHFFFAOYSA-N

Methoxetamine, abbreviated as MXE, is a dissociative hallucinogen that has been sold as a designer drug.[1] [6] It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically to increase the antidepressant effects of ketamine.[6] [7]

MXE is an arylcyclohexylamine. It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP.

Recreational use

Effects

MXE is reported to have a similar effect to ketamine.[8] It was often believed to possess opioid properties due to its structural similarity to 3-HO-PCP,[6] but this assumption is not supported by data, which shows insignificant affinity for the μ-opioid receptor by the compound. Recreational use of MXE has been associated with hospitalizations from high and/or combined consumption in the US and UK.[9] Acute reversible cerebellar toxicity has been documented in three cases of hospital admission due to MXE overdose, lasting for between one and four days after exposure.[10]

MXE was designed in part in an attempt to avoid the urotoxicity associated with ketamine abuse; it was thought the compound's increased potency and reduced dose would limit the accumulation of urotoxic metabolites in the bladder.[6] [7] Like ketamine, MXE has been found to produce bladder inflammation and fibrosis after high dose chronic administration in mice, although the dosages used were quite large.[11] Reports of urotoxicity in humans have yet to appear in the medical literature.[6]

Pharmacology

Pharmacodynamics

Methoxetamine[12] [13]
Site Ki (nM) Action Species Ref

 		259 Antagonist Human
>10,000 Human
>10,000 Human
>10,000 Human
>10,000 Human
>10,000 Guinea pig
>10,000 Rat
>10,000 Human
>10,000 Human
481
2,400 (IC50) 		Inhibitor Human
[14]
>10,000
20,000 (IC50) 		Inhibitor Human
>10,000
33,000 (IC50) 		Inhibitor Human
Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.

MXE acts mainly as a selective and high-affinity NMDA receptor antagonist, specifically of the dizocilpine (MK-801) site (Ki = 257 nM).[15] It produces ketamine-like effects.[16] In addition to antagonism of the NMDA receptor, MXE has been found to act as a serotonin reuptake inhibitor (Ki = 479 nM; IC50 = 2,400 nM). Conversely, it shows little or no effect on the reuptake of dopamine and norepinephrine (Ki and IC50 > 10,000 nM). Nonetheless, MXE has been found to activate dopaminergic neurotransmission, including in the mesolimbic reward pathway. This is a characteristic that it shares with other NMDA receptor antagonists, including ketamine, PCP, and dizocilpine (MK-801). Animal studies suggest MXE may have rapidly-acting antidepressant effects similar to those of ketamine.[17] A study that assessed binding of MXE at 56 sites including neurotransmitter receptors and transporters found that MXE had Ki values of >10,000 nM for all sites except the dizocilpine site of the NMDA receptor and the serotonin transporter (SERT).

Pharmacokinetics

MXE has a longer duration of action than that of ketamine.[18]

Chemistry

MXE is an arylcyclohexylamine and a derivative of eticyclidine (PCE). It can also be thought of as the β-Keto-derivative of 3-methoxyeticyclidine (3-MeO-PCE), or the N-ethyl homologue of methoxmetamine (MXM) and methoxpropamine (MXPr). It is closely related structurally to ketamine, and more distantly to PCP.

MXE hydrochloride is soluble in ethanol up to 10 mg/ml at 25 °C.[19]

Detection in body fluids

A forensic standard of MXE is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[20]

History

The qualitative effects of MXE were first described online in May 2010 and the compound became commercially available on a small scale in September 2010.[1] [6] By November the use and sale of the MXE had increased enough for it to be formally identified by the European Monitoring Centre for Drugs and Drug Addiction. By July 2011, the EMCDDA had identified 58 websites selling the compound at a cost of 145–195 euros for 10 grams.[21]

Society and culture

Media coverage

Mixmag reported in January 2012, that people in the dance music and clubbing community have given MXE the slang name 'roflcoptr'.[22] Vice commented that it was likely that the phrase will only be used by "the same politicians, parents and journalists" who called mephedrone 'meow meow'.[23] After being called mexxy in UK Home Office press releases, the media adopted the name.[24] [25]

A literature review was published in March 2012 which looked at scientific literature and information on the web. It concluded that "the online availability of information on novel psychoactive drugs, such as MXE, may constitute a pressing public health challenge. Better international collaboration levels and novel forms of intervention are necessary to tackle this fast-growing phenomenon."[26]

Legal status

Brazil

MXE became classified as a narcotic in Brazil in February 2014.[27]

Canada

As of January 2010 MXE is a controlled substance in Canada.[28]

China

As of October 2015 MXE is a controlled substance in China.[29]

European Union

On 16 June 2014, the European Commission proposed that MXE be banned across the European Union, subjecting those in violation to criminal sanctions. This is following the procedure for risk-assessment and control of new psychoactive substances set up by the council: Decision 2005/387/JHA.[30]

Finland

Scheduled in "government decree on narcotic substances, preparations and plants" and is hence illegal.[31]

Israel

MXE became classified as an illegal narcotic in Israel in May 2012.[32] [33]

Japan

MXE became a controlled substance in Japan from 1 July 2012, by amendment to the Pharmaceutical Affairs Law.[34] [35]

Poland

MXE is a controlled substance (group II-P) making it illegal to produce, sell or possess in The Republic of Poland as of 1 July 2015.[36]

Russia

MXE has been a controlled substance in Russia since October 2011.[37]

Sweden

MXE became classified as a narcotic in Sweden in late February 2012.[38]

Switzerland

MXE has been illegal in Switzerland since December 2011.[39]

United Kingdom

Prior to March 2012, MXE was not controlled by the UK's Misuse of Drugs Act.[40] In March 2012, the Home Office referred MXE to the Advisory Council on the Misuse of Drugs for possible temporary controlling under the powers given in the Police Reform and Social Responsibility Act 2011.[41] [42] The ACMD gave their advice on 23 March, with the chair commenting that "the evidence shows that the use of methoxetamine can cause harm to users and the ACMD advises that it should be subject to a temporary class drug order."[43] In April 2012, MXE was placed under temporary class drug control, which prohibited its import and sale for 12 months.[44]

Theresa May commented in her reply to the ACMD that "the next step in this process is for the ACMD to undertake a full assessment of MXE for consideration for its permanent control under the 1971 Act." She goes on to say that she hopes the ACMD will do this as a part of the review of ketamine, "including its analogues" and that this review will be completed "within the 12 months from the making of the current order".[45]

On 18 October 2012 the ACMD released a report about MXE, saying that the "harms of methoxetamine are commensurate with Class B of the Misuse of Drugs Act (1971)", despite the fact that the act does not classify drugs based on harm. The report went on to suggest that all analogues of MXE should also become class B drugs and suggested a catch-all clause covering both existing and unresearched arylcyclohexamines.

MXE ceased to be covered by the temporary prohibition on 26 February 2013, when it became classified as a Class B drug.[46]

United Nations

MXE was made a schedule II drug in November 2016.[47]

United States

On June 6, 2022, the U.S. Drug Enforcement Administration published a final rule placing MXE in Schedule I of the Controlled Substances Act.[48]

Alabama
  • MXE is a Schedule I controlled substance in the state of Alabama making it illegal to buy, sell, or possess in Alabama.[49]
    Florida
  • MXE is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[50]
    Utah
  • MXE is a controlled substance in the state of Utah making it illegal to buy, sell, or possess in Utah.[51]

    External links

    Notes and References

    1. EMCDDA Annual Report 2010. European Monitoring Centre for Drugs and Drug Addiction. 2010. 2012-01-23. live. https://web.archive.org/web/20120314043454/http://www.emcdda.europa.eu/attachements.cfm/att_132857_EN_EMCDDA-Europol%20Annual%20Report%202010A.pdf. 14 March 2012.
    2. Web site: Anvisa . Brazilian Health Regulatory Agency . 2023-07-24 . RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial . Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control. live . https://web.archive.org/web/20230827163149/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451 . 2023-08-27 . 2023-08-27 . . pt-BR . 2023-07-25.
    3. Web site: Federal Register . FederalRegister.gov. 21 June 2022.
    4. Web site: Substance Details Methoxetamine . 2024-01-22.
    5. Kjellgren A, Jonsson K . Methoxetamine (MXE)--a phenomenological study of experiences induced by a "legal high" from the internet . Journal of Psychoactive Drugs . 45 . 3 . 276–286 . 2013 . 24175493 . 3756617 . 10.1080/02791072.2013.803647 .
    6. Morris H, Wallach J . From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs . Drug Testing and Analysis . 6 . 7–8 . 614–632 . 2014 . 24678061 . 10.1002/dta.1620 .
    7. Web site: Interview with a ketamine chemist: or to be more precise, an arylcyclohexylamine chemist . Morris H . 2011-02-11 . Vice Magazine . 2012-01-23 . live . https://web.archive.org/web/20120130183103/http://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2 . 30 January 2012.
    8. Kjellgren A, Jonsson K . Methoxetamine (MXE)--a phenomenological study of experiences induced by a "legal high" from the internet . Journal of Psychoactive Drugs . 45 . 3 . 276–286 . 2013 . 24175493 . 3756617 . 10.1080/02791072.2013.803647 .
    9. Wood DM, Davies S, Puchnarewicz M, Johnston A, Dargan PI . Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine . European Journal of Clinical Pharmacology . 68 . 5 . 853–856 . May 2012 . 22205276 . 10.1007/s00228-011-1199-9 . 4084801 .
    10. Shields JE, Dargan PI, Wood DM, Puchnarewicz M, Davies S, Waring WS . Methoxetamine associated reversible cerebellar toxicity: three cases with analytical confirmation . Clinical Toxicology . 50 . 5 . 438–440 . June 2012 . 22578175 . 10.3109/15563650.2012.683437 . 40114091 .
    11. Dargan PI, Tang HC, Liang W, Wood DM, Yew DT . Three months of methoxetamine administration is associated with significant bladder and renal toxicity in mice . Clinical Toxicology . 52 . 3 . 176–180 . March 2014 . 24580056 . 10.3109/15563650.2014.892605 . 34284740 .
    12. Web site: PDSP Ki Database . Psychoactive Drug Screening Program (PDSP) . Roth BL, Driscol J . Bryan Roth . University of North Carolina at Chapel Hill and the United States National Institute of Mental Health . 14 August 2017 .
    13. Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L . The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor . PLOS ONE . 8 . 3 . e59334 . 2013 . 23527166 . 3602154 . 10.1371/journal.pone.0059334 . free . 2013PLoSO...859334R .
    14. Hondebrink L, Kasteel EE, Tukker AM, Wijnolts FM, Verboven AH, Westerink RH . Neuropharmacological characterization of the new psychoactive substance methoxetamine . Neuropharmacology . 123 . 1–9 . September 2017 . 28454981 . 10.1016/j.neuropharm.2017.04.035 . free . 1874/359894 . free .
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    16. Hofer KE, Grager B, Müller DM, Rauber-Lüthy C, Kupferschmidt H, Rentsch KM, Ceschi A . Ketamine-like effects after recreational use of methoxetamine . Annals of Emergency Medicine . 60 . 1 . 97–99 . July 2012 . 22237166 . 10.1016/j.annemergmed.2011.11.018 .
    17. Botanas CJ, Bryan de la Peña J, Custodio RJ, Joy Dela Peña I, Kim M, Woo T, Kim HJ, Kim HI, Chang Cho M, Lee YS, Cheong JH . 6 . Methoxetamine produces rapid and sustained antidepressant effects probably via glutamatergic and serotonergic mechanisms . Neuropharmacology . 126 . 121–127 . November 2017 . 28867363 . 10.1016/j.neuropharm.2017.08.038 . 30870722 .
    18. Horsley RR, Lhotkova E, Hajkova K, Jurasek B, Kuchar M, Palenicek T . Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-Behavioural, pharmacokinetic and metabolic studies in the Wistar rat . Brain Research Bulletin . 126 . Pt 1 . 102–110 . September 2016 . 27155360 . 10.1016/j.brainresbull.2016.05.002 . 3955788 .
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    22. News: Beaumont-Thomas B . Methoxetamine is a new chemical analogue of ketamine. It's legal, it's cheap and it's trippy as hell - but is it safe?. Mixmag. London, UK . 249 . 2012-01-18 . 60 .
    23. News: We Interviewed the Inventor of Roflcoptr, the New Drug Britain's Panicking About . Miller A . Vice Magazine . 2011-02-11 . 2011-02-11 . live . https://web.archive.org/web/20120125081300/http://www.vice.com/en_uk/read/we-interviewed-the-man-who-invented-roflecoptr . 25 January 2012.
    24. News: Pair hospitalised after taking designer drug mexxy . 7 April 2014 . BBC News . live . https://web.archive.org/web/20140412003310/http://www.bbc.com/news/uk-wales-north-west-wales-26928186 . 12 April 2014.
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    26. Corazza O, Schifano F, Simonato P, Fergus S, Assi S, Stair J, Corkery J, Trincas G, Deluca P, Davey Z, Blaszko U, Demetrovics Z, Moskalewicz J, Enea A, di Melchiorre G, Mervo B, di Furia L, Farre M, Flesland L, Pasinetti M, Pezzolesi C, Pisarska A, Shapiro H, Siemann H, Skutle A, Enea A, di Melchiorre G, Sferrazza E, Torrens M, van der Kreeft P, Zummo D, Scherbaum N . 6 . Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamine . Human Psychopharmacology . 27 . 2 . 145–149 . March 2012 . 22389078 . 10.1002/hup.1242 . 29318833 . free .
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    28. Web site: 2011-01-31. Status Decision Of Controlled And Non-Controlled Substance(s). dead. https://web.archive.org/web/20160409135922/http://isomerdesign.com/Cdsa/HC/StatusDecisions/A-2013-00235%20-%20PDFs/C-Methoxetamine-2011-01-31.pdf. 2016-04-09. 2021-01-29.
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    51. http://le.utah.gov/xcode/Title58/Chapter37/58-37-S4.2.html Utah Code 58-37-4.2. Listed controlled substances.

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