Methionyl-tRNA formyltransferase explained

methionyl-tRNA formyltransferase
Altnames:N10-formyltetrahydrofolic-methionyl-transfer ribonucleic, transformylase, formylmethionyl-transfer ribonucleic synthetase, methionyl ribonucleic formyltransferase, methionyl-tRNA Met formyltransferase, methionyl-tRNA transformylase, methionyl-transfer RNA transformylase, methionyl-transfer ribonucleate methyltransferase, methionyl-transfer ribonucleic transformylase
Ec Number:2.1.2.9
Cas Number:9015-76-3
Go Code:0004479
Methionyl-tRNA formyltransferase

In enzymology, a methionyl-tRNA formyltransferase is an enzyme that catalyzes the chemical reaction

\rightleftharpoons

tetrahydrofolate + N-formylmethionyl-tRNAfMet

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase. This enzyme participates in three metabolic pathways: methionine metabolism, one carbon pool by folate, and aminoacyl-tRNA biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References