Methaphenilene Explained

Methaphenilene is an antihistamine and anticholinergic.

Synthesis

Methaphenilene can be synthesized from N,N-dimethyl--phenylethane-1,2-diamine by alkylation with 2-(chloromethyl)thiophene.^[1]

See also

• Thenalidine
• Methapyrilene

Notes and References

1. Leonard F, Solmssen UV . Thenyl Substituted Diamines with Antihistaminic Activity . Journal of the American Chemical Society . 70 . 6 . 2064–7 . June 1948 . 18863797 . 10.1021/ja01186a023 .