Methanediol Explained

Methanediol, also known as formaldehyde monohydrate or methylene glycol, is an organic compound with chemical formula . It is the simplest geminal diol. In aqueous solutions it coexists with oligomers (short polymers). The compound is closely related and convertible to the industrially significant derivatives paraformaldehyde, formaldehyde, and 1,3,5-trioxane .

Methanediol is a product of the hydration of formaldehyde. The equilibrium constant for hydration is estimated to be 103,[1] predominates in dilute (<0.1%) solution. In more concentrated solutions, it oligomerizes to .

Occurrence

The dianion, methanediolate, is believed to be an intermediate in the crossed Cannizzaro reaction.

Gaseous methanediols can be generated by electron irradiation and sublimation of a mixture of methanol and oxygen ices.[2]

Methanediol is believed to occur as an intermediate in the decomposition of carbonyl compounds in the atmosphere, and as a product of ozonolysis on these compounds.[2]

Safety

Methanediol, rather than formaldehyde, is listed as one of the main ingredients of "Brazilian blowout", a hair-straightening formula marketed in the United States. The equilibrium with formaldehyde has caused concern since formaldehyde in hair straighteners is a health hazard.[3] [4] Research funded by the Professional Keratin Smoothing Council (PKSC), an industry association that represents selected manufacturers of professional-use only keratin smoothing products, has disputed the risk.[5]

See also

Notes and References

  1. Eric V. Anslyn, Dennis A. Dougherty (2006), Modern physical organic chemistry. University Science Books. . 1095 pages
  2. Zhu . Cheng . Kleimeier . N. Fabian . Turner . Andrew M. . Singh . Santosh K. . Fortenberry . Ryan C. . Kaiser . Ralf I. . Synthesis of methanediol [CH 2 (OH) 2 ]: The simplest geminal diol . Proceedings of the National Academy of Sciences . 4 January 2022 . 119 . 1 . e2111938119 . 10.1073/pnas.2111938119 . 34969838 . 8740743 . 2022PNAS..11911938Z .
  3. Web site: Hair Smoothing Products That Could Release Formaldehyde. Occupational Safety and Health Administration. www.osha.gov.
  4. Web site: Industry News. SpecialChem .
  5. Golden. R.. Valentini. M.. Formaldehyde and methylene glycol equivalence: Critical assessment of chemical and toxicological aspects. Regulatory Toxicology and Pharmacology. July 2014. 69. 2. 178–186. 10.1016/j.yrtph.2014.03.007. 24709515. free.