Methanediamine Explained

Methanediamine is the simplest diamine. Its chemical formula is CH2(NH2)2. Although methanediamine can only exists transiently in solution,[1] its hydrochloride has been used in chemical synthesis since 1914.[2] The hydrochloride is useful for the synthesis of primary amides from amino acids.[3]

Methylamine and ammonia will react to form methanediamine when exposed under energetic electrons, just like conditions similar to cold molecular clouds.[1] Since methanediamine is the simplest molecule to contain the N-C-N moiety, it could be a vital intermediate in the abiogenesis of heterocyclic compounds that contain the N-C-N moiety, such as nucleobases.[1]

Notes and References

  1. Marks . Joshua H. . Wang . Jia . Fortenberry . Ryan C. . Kaiser . Ralf I. . Preparation of methanediamine (CH2(NH2)2)—A precursor to nucleobases in the interstellar medium . Proceedings of the National Academy of Sciences . 119 . 51 . 2022-12-20 . 0027-8424 . 36508671 . 9907108 . 10.1073/pnas.2217329119.
  2. Knudsen . Peter . Über Methylendiamin . Berichte der deutschen chemischen Gesellschaft . 47 . 3 . 1914 . 0365-9496 . 10.1002/cber.19140470355 . 2698–2701.
  3. Galaverna . Gianni . Corradini . Roberto . Dossena . Arnaldo . Marchelli . Rosangela . Diaminomethane dihydrochloride, a novel reagent for the synthesis of primary amides of amino acids and peptides from active esters . International Journal of Peptide and Protein Research . 42 . 1 . 1993 . 0367-8377 . 10.1111/j.1399-3011.1993.tb00349.x . 53–57.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Methanediamine".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.