Methamnetamine Explained

Methamnetamine (also known as methylnaphetamine, MNA, MNT and PAL-1046) is a triple monoamine releasing agent and N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine.^{[1] [2] [3]} It has been sold online as a designer drug.^{[4] [5]}

It acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC₅₀ values of 13 nM, 34 nM, and 10 nM, respectively.^[1]

Legal status

Methamnetamine is illegal in Japan.^[6]

See also

• 2-MAPB
• 5-MAPBT
• BMAPN
• Naphthylaminopropane
• HDEP-28
• HDMP-28
• Naphyrone
• WF-23

Notes and References

1. Rothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE . Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters . The Journal of Pharmacology and Experimental Therapeutics . 341 . 1 . 251–262 . April 2012 . 22271821 . 3364510 . 10.1124/jpet.111.188946 .
2. Youn DH, Kim JM, Hong YK, Park SI, Lee JM, Kim YH, Park CW, Kang MS . 6 . Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study . Psychopharmacology . 238 . 8 . 2155–2165 . August 2021 . 33811503 . 10.1007/s00213-021-05840-9 . 232773019 .
3. Hong YK, Kim YH, Lee JM, Yoo HH, Choi SO, Kang MS . Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry . International Journal of Legal Medicine . 135 . 4 . 1471–1476 . July 2021 . 33928430 . 10.1007/s00414-021-02594-z . 233451101 .
4. Web site: Methamnetamine . WEDINOS.
5. Web site: Methamnetamine . New Synthetic Drugs Database.
6. Web site: 指定薬物名称・構造式一覧（平成27年9月16日現在）. List of designated drug names and structural formulas (as of September 16, 2015) . 厚生労働省 . Ministry of Health, Labour and Welfare . 16 September 2015 . Japanese . 8 October 2015.