Methallylescaline Explained

4-methylallyloxy-3,5-dimethoxyphenethylamine (more commonly know as methallylescaline, and abbreviated as MAL) is a lesser-known psychedelic drug. It is the 4-methyl analog of allylescaline. MAL was first synthesized by Alexander Shulgin. In his book PiHKAL, the dosage range is listed as 40–65 mg, and the duration is listed as 12–16 hours.^[1] Little data exists about the pharmacological properties, metabolism, and toxicity of MAL. The effects of MAL are comparable to that of other mescaline analogs, although with a longer duration. MAL has been sold as a designer drug.^{[2] [3]} At very high doses (30 mg/kg) MAL, as well as the psychedelic amphetamine DOI, causes neuroinflammation and loss of serotonergic neurons in mice.^[4]

Legal status

Methallylescaline is illegal in Sweden as of 26 January 2016.^[5]

See also

• 2C-T-3
• 3C-MAL
• Phenethylamine

Notes and References

1. Web site: Methallylescaline . PiHKAL .
2. Clare BW . QSAR of benzene derivatives: comparison of classical descriptors, quantum theoretic parameters and flip regression, exemplified by phenylalkylamine hallucinogens . Journal of Computer-aided Molecular Design . 16 . 8–9 . 611–33 . 2002 . 12602954 . 10.1023/a:1021966231380 . 2002JCAMD..16..611C . 9948738 .
3. Coelho Neto J . Rapid detection of NBOME's and other NPS on blotter papers by direct ATR-FTIR spectrometry . Forensic Science International . 252 . 87–92 . July 2015 . 25965305 . 10.1016/j.forsciint.2015.04.025 .
4. Custodio R . October 2023 . Serotonin 2C receptors are also important in head-twitch responses in male mice . Psychopharmacology (Berl) . 10.1007/s00213-023-06482-9 . 37882810.
5. Web site: 31 nya ämnen kan klassas som narkotika eller hälsofarlig vara . Folkhälsomyndigheten . Swedish . November 2015.