Methadone intermediate explained

Iupac Name:4-cyano-2-dimethylamino-4,4-diphenylbutane
Width:160
Legal Br:A1
Legal Br Comment:[1]
Legal Un:N I
Legal De:Anlage II
Routes Of Administration:N/A
Cas Number:125-79-1
Unii:0GYB2HJA89
Atc Prefix:none
Pubchem:31331
Kegg:C22686
Chemspiderid:29065
C:19
H:22
N:2
Smiles:CC(CC(C#N)(C1=CC=CC=C1)C2=CC=CC=C2)N(C)C
Stdinchi:1S/C19H22N2/c1-16(21(2)3)14-19(15-20,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-13,16H,14H2,1-3H3
Stdinchikey:GJJQIGFCGLPOQK-UHFFFAOYSA-N

Methadone intermediate (Pre-methadone, Methadone nitrile, Dimethylaminodiphenylbutanonitrile) is a methadone precursor scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9254. The 2014 annual manufacturing quota was 32 875 kilos.[2] It is listed as a Schedule I drug in Canada,[3] but is only significant as a precursor for methadone, as it does not have analgesic activity in its own right, though it does show some atropine-like activity.[4]

See also

Notes and References

  1. Web site: Anvisa . Brazilian Health Regulatory Agency . 2023-03-31 . RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial . Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control. live . https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 . 2023-08-03 . 2023-08-16 . . pt-BR . 2023-04-04.
  2. Web site: Quotas - Conversion Factors for Controlled Substances . 2016-02-28 . 2016-03-02 . https://web.archive.org/web/20160302162948/http://deadiversion.usdoj.gov/quotas/conv_factor/index.html . dead .
  3. Web site: Controlled Drugs and Substances Act (S.C. 1996, c. 19) . Justice Laws Website . 24 November 2023 . Government of Canada .
  4. Book: Janssen PA . VII Nitriles . Synthetic Analgesics . 1 . Diphenylpropylamines . Pergamon Press . 1960 . 122–128 . 59-13814 .