Metfendrazine Explained

Metfendrazine (developmental code names HM-11, MO-482), also known as methphendrazine, is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine family.^{[1] [2]} It was investigated as an antidepressant, but was never marketed.

Chemistry

Metfendrazine, also known as methamphetamine hydrazide, is a phenethylamine, amphetamine, and hydrazine derivative.

It is an analogue and derivative of phenelzine (phenethylamine hydrazide) and pheniprazine (amphetamine hydrazide), as well as of phenethylamine, amphetamine, and methamphetamine.

Notes and References

1. Miquel J, Mijan CD . Metfendrazine, a new inhibitor of monoamine oxidase . Archivos del Instituto de Farmacología Experimental . Madrid . 14 . 47–59 . 1962.
2. Kothari NJ, Saunders JC, Kline NS, Griffen JA . A comparison of perphenazine, proketazine, nialamide and MO-482 in chronic schizophrenics . The American Journal of Psychiatry . 117 . 4 . 358–360 . October 1960 . 13753478 . 10.1176/ajp.117.4.358 .