Metazosin Explained

Metazosin is an antihypertensive α1-adrenergic receptor antagonist.[1] [2]

Synthesis

The amide (3) is formed when piperazine is reacted with 2-methoxypropionylchloride (2). Metazosin is the product when this intermediate is reacted with the substituted quinazoline (4).[3] [4]

Notes and References

  1. 1981860. 1990. Trcka. V. König. J. Mácová. S. Smíd. M. Helfert. I. Votavová. M. Remesová. J. Nezádalová. E. Pharmacology of a new antihypertensive agent, metazosin (Kenosin). 39. 6. 266–74. Ceskoslovenska Farmacie.
  2. 2575403. 1989. Lapka. R. Rejholec. V. Sechser. T. Peterková. M. Smíd. M. Interspecies pharmacokinetic scaling of metazosin, a novel alpha-adrenergic antagonist. 10. 6. 581–9. Biopharmaceutics & Drug Disposition. 10.1002/bdd.2510100607.
  3. US . 4775673 . Jan Koenig, Miroslav Rajsner, Vaclav Trcka, Sverluse Macova . Substituted acylpiperazinoquinazolines and pharmaceutical compositions containing same . patent . 1988-10-04 . 1986-04-14 . Spofa Spojene Podniky Pro Zdravotnickou Vyrobu.
  4. Web site: Metazosin . chemdrug.com . 2024-07-08.

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