Metanx Explained

Metanx is a prescription medical food made by Alfasigma that contains L-methylfolate (as Metafolin, a calcium salt of vitamin B₉), methylcobalamin (vitamin B₁₂) and pyridoxal 5'-phosphate (vitamin B₆). It is a vitamin B supplement. Metanx is indicated for the dietary management of peripheral neuropathy (i.e. DPN).^[1]

Ingredients

Metanx contains the following active ingredients (per capsule):

• Folate
• L-methylfolate (Metafolin): 3 mg
• Pyridoxal 5'-phosphate: 35 mg
• Methylcobalamin: 2 mg^[2]

Indication and usage

Metanx is used for treating:

• Painful diabetic neuropathy,^[3]
• Diabetic foot ulcers,
• Endothelial dysfunction associated with diabetic peripheral neuropathy,
• Hyperhomocysteinemia.

Notes and References

1. Metanx package insert, 2014
2. Book: Smith HS, Pappagallo M . Essential Pain Pharmacology: The Prescriber's Guide . Metanx: Folate, B₆, B₁₂ Vitamins Combination . https://books.google.com/books?id=ymry3quAw6IC&pg=PA521 . Cambridge University Press . 2012 . 978-0-521-75910-6 . 521. (Google Books)
3. Book: Liptan G . The FibroManual: A Complete Fibromyalgia Treatment Guide for You and Your Doctor. Ballantine Books . 237 . 2016 . 9781101967201. (Google Books)