Metacetamol Explained

Metacetamol (developmental code name BS-749), also known as 3-hydroxyacetanilide and AMAP, is a non-toxic regioisomer of paracetamol with analgesic and antipyretic properties, but has never been marketed as a drug.[1] [2]

Metacetamol is known to have several polymorphs.[3] Form II is metastable, while form I is stable. Metacetamol polymorph II transforms to form I upon water moisture or direct contact with water and other popular solvents. Metacetamol II form may be obtained on cooling in narrow temperature regime.[4]

Notes and References

  1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 67–.
  2. Web site: CHEBI:76987 - metacetamol .
  3. McGregor L, Rychkov DA, Coster PL, Day S, Drebushchak VA, Achkasov AF, Nichol GS, Pulham CR, Boldyreva EV . 6 . 2015 . A new polymorph of metacetamol . CrystEngComm . en . 17 . 32 . 6183–6192 . 10.1039/C5CE00910C . 1466-8033.
  4. Drebushchak VA, McGregor L, Rychkov DA . February 2017 . Cooling rate "window" in the crystallization of metacetamol form II . Journal of Thermal Analysis and Calorimetry . en . 127 . 2 . 1807–1814 . 10.1007/s10973-016-5954-0 . 99391719 . 1388-6150.

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