Mesostriatal system explained

The Mesostriatal system is a term sometimes used to identify the midbrain dopamine projections into the striatum and cortex. It has been described as a combination of the mesolimbic and nigrostriatal dopamine projections, and has been described as being partially asymmetric.^[1]

Research

It has been referred to in the context of α-melanocyte stimulating hormones effect on dopamine activity in the mesostriatal system.^[2] Research identifying cholinergic projections into these mesostriatal nuclei have been performed, revealing that the midbrain dopaminergic nuclei receive projections from the pedunculopontine tegmentum and laterodorsal pontine tegmentum.^[3] The mesostriatal system has also been implicated in reward learning, coding predictions.^[4] This anatomical classification has also been used in the context of parkinson research.^[5]

Notes and References

1. Molochnikov. Ilana. Cohen. Dana. Hemispheric differences in the mesostriatal dopaminergic system. Frontiers in Systems Neuroscience. 1 January 2014. 8. 110. 10.3389/fnsys.2014.00110. 24966817. 4052732. free.
2. Roseberry. Aaron G.. Stuhrman. Katherine. Dunigan. Anna I.. Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein. Neuroscience and Biobehavioral Reviews. 1 September 2015. 56. 15–25. 10.1016/j.neubiorev.2015.06.020. 26116876. 43619316. 1873-7528.
3. Zhou. Fu-Ming. Wilson. Charles. Dani. John A.. Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. The Neuroscientist. 1 February 2003. 9. 1. 23–36. 12580337. 1073-8584. 10.1177/1073858402239588. 8266496.
4. Chase. Henry W.. Kumar. Poornima. Eickhoff. Simon B.. Dombrovski. Alexandre Y.. Reinforcement Learning Models and Their Neural Correlates: An Activation Likelihood Estimation Meta-Analysis. Cognitive, Affective, & Behavioral Neuroscience. 9 January 2017. 15. 2. 435–459. 10.3758/s13415-015-0338-7. 25665667. 4437864. 1530-7026.
5. Cools. A. R.. Role of neostriatal and mesostriatal or mesolimbic dopaminergic fibres in Parkinson's disease with and without dementia: prospects, concepts and facts. Yakubutsu, Seishin, Kodo = Japanese Journal of Psychopharmacology. 1 March 1990. 10. 1. 15–34. 2220127. 0285-5313.