| Settlement Type: | Mesoregion |
| Official Name: | Mesoregion of Jequitinhonha |
| Mapsize: | 250px |
| Subdivision Type: | Country |
| Subdivision Name: |  Brazil |
| Subdivision Type1: | Region |
| Subdivision Name1: | Southeast |
| Subdivision Type2: | State |
| Area Total Km2: | 50143.249 |
| Population As Of: | 2010/IBGE |
| Population Total: | 981121 |
| Population Density Km2: | 23.8 |
| Timezone: | BRT |
| Utc Offset: | -3 |
| Timezone Dst: | BRST |
| Utc Offset Dst: | -2 |
| Coordinates: | -16.85°N -42.07°W |
| Area Code: | +55 33, 38 |
| Postal Code Type: | CEP postal code |
Vale do Jequitinhonha (English: [[Jequitinhonha River]] valley), or simply Jequitinhonha, is one of the twelve mesoregions of the Brazilian state of Minas Gerais. It is composed of 51 municipalities[1] spread across five microregions.