Mesoderm-specific transcript homolog protein explained

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.^{[1] [2]}

This gene encodes a member of the Alpha/beta hydrolase superfamily and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promoter switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.

Further reading

• Kobayashi S, Kohda T, Miyoshi N, etal . Human PEG1/MEST, an imprinted gene on chromosome 7 . Hum. Mol. Genet. . 6 . 5 . 781–6 . 1997 . 9158153 . 10.1093/hmg/6.5.781 . free .
• Riesewijk AM, Hu L, Schulz U, etal . Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses . Genomics . 42 . 2 . 236–44 . 1997 . 9192843 . 10.1006/geno.1997.4731 . 2066/24440 . 24034813 . free .
• Cuisset L, Le Stunff C, Dupont JM, etal . PEG1 expression in maternal uniparental disomy 7 . Ann. Genet. . 40 . 4 . 211–5 . 1998 . 9526615 .
• Riesewijk AM, Blagitko N, Schinzel AA, etal . Evidence against a major role of PEG1/MEST in Silver-Russell syndrome . Eur. J. Hum. Genet. . 6 . 2 . 114–20 . 1998 . 9781054 . 10.1038/sj.ejhg.5200164 . free .
• Pedersen IS, Dervan PA, Broderick D, etal . Frequent loss of imprinting of PEG1/MEST in invasive breast cancer . Cancer Res. . 59 . 21 . 5449–51 . 1999 . 10554015 .
• Kosaki K, Kosaki R, Craigen WJ, Matsuo N . Isoform-Specific Imprinting of the Human PEG1/MEST Gene . Am. J. Hum. Genet. . 66 . 1 . 309–12 . 2000 . 10631159 . 10.1086/302712 . 1288335 .
• Mayer W, Hemberger M, Frank HG, etal . Expression of the imprinted genes MEST/Mest in human and murine placenta suggests a role in angiogenesis . Dev. Dyn. . 217 . 1 . 1–10 . 2000 . 10679925 . 10.1002/(SICI)1097-0177(200001)217:1<1::AID-DVDY1>3.0.CO;2-4 . free .
• Hayashida S, Yamasaki K, Asada Y, etal . Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32 . Genomics . 66 . 2 . 221–5 . 2000 . 10860668 . 10.1006/geno.2000.6206 .
• Russo S, Bedeschi MF, Cogliati F, etal . Maternal chromosome 7 hetero/isodisomy in Silver-Russell syndrome and PEG1 biallelic expression . Clin. Dysmorphol. . 9 . 3 . 157–62 . 2000 . 10955473 . 10.1097/00019605-200009030-00001 .
• Kerjean A, Dupont JM, Vasseur C, etal . Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis . Hum. Mol. Genet. . 9 . 14 . 2183–7 . 2000 . 10958657 . 10.1093/hmg/9.14.2183 . free .
• Kohda M, Hoshiya H, Katoh M, etal . Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma . Mol. Carcinog. . 31 . 4 . 184–91 . 2001 . 11536368 . 10.1002/mc.1053 . 46249386 .
• Miozzo M, Grati FR, Bulfamante G, etal . Post-zygotic origin of complete maternal chromosome 7 isodisomy and consequent loss of placental PEG1/MEST expression . Placenta . 22 . 10 . 813–21 . 2002 . 11718568 . 10.1053/plac.2001.0728 .
• Kobayashi S, Uemura H, Kohda T, etal . No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients . Am. J. Med. Genet. . 104 . 3 . 225–31 . 2002 . 11754049 . 10.1002/ajmg.10022 . free .
• Li T, Vu TH, Lee KO, etal . An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa . J. Biol. Chem. . 277 . 16 . 13518–27 . 2002 . 11821432 . 10.1074/jbc.M200458200 . free .
• Bonora E, Bacchelli E, Levy ER, etal . Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region . Mol. Psychiatry . 7 . 3 . 289–301 . 2002 . 11920156 . 10.1038/sj.mp.4001004 . free .
• Pedersen IS, Dervan P, McGoldrick A, etal . Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer . Hum. Mol. Genet. . 11 . 12 . 1449–53 . 2002 . 12023987 . 10.1093/hmg/11.12.1449 . free .
• Nakabayashi K, Bentley L, Hitchins MP, etal . Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32 . Hum. Mol. Genet. . 11 . 15 . 1743–56 . 2003 . 12095916 . 10.1093/hmg/11.15.1743 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . 2003Sci...300..767S .

Notes and References

1. Nishita Y, Yoshida I, Sado T, Takagi N . Genomic imprinting and chromosomal localization of the human MEST gene . Genomics . 36 . 3 . 539–42 . Feb 1997 . 8884280 . 10.1006/geno.1996.0502 .
2. Web site: Entrez Gene: MEST mesoderm specific transcript homolog (mouse).