Mesocapromys is a genus of rodent in the subfamily Capromyinae. The genus is restricted to Cuba and associated islands.
Mesocapromys contains the five following species:
Within Capromyidae, the closest relative of Mesocapromys is the genus Mysateles. Both genera are the sister group to Capromys, and then Geocapromys is a more distant genus. In turn, these four genera belong to the tribe Capromyini, and are the sister group to Plagiodontia.