3-Mercaptopyruvic acid explained

3-Mercaptopyruvic acid is an intermediate in cysteine metabolism. It has been studied as a potential treatment for cyanide poisoning, but its half-life is too short for it to be clinically effective.[1] Instead, prodrugs, such as sulfanegen, are being evaluated to compensate for the short half-life of 3-mercaptopyruvic acid.[2]

See also

Notes and References

  1. 12871026 . 2003 . Nagahara . N . Li . Q . Sawada . N . Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification? . 3 . 3 . 198–204 . Current Drug Targets. Immune, Endocrine and Metabolic Disorders . 10.2174/1568008033340162.
  2. 20705081 . 2010 . Brenner . M . Kim . JG . Lee . J . Mahon . SB . Lemor . D . Ahdout . R . Boss . GR . Blackledge . W . Jann . L . Nagasawa . HT . Patterson . SE . Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity . 248 . 3 . 269–76 . 10.1016/j.taap.2010.08.002 . 3382974 . Toxicology and Applied Pharmacology.

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