Meralluride Explained

Meralluride is a mercurial diuretic.[1]

In a 1963 study done with rats, it was thought to act on the proximal tubules of the kidneys.[1] Studies in the late 1970s showed the compound had antimicrobial effect against Proteus bacteria responsible for urinary tract infections, with varying degrees of effectiveness based on the substances mixed with the drug.[2]

Published toxicity reports include one patient who "experienced violent delayed febrile reactions after the fifth, sixth, and seventh intramuscular injections of Mercuhydrin".[3] Studies from Japan showed the compound caused ventricular fibrillation in a high percentage of animals when compared to furosemide; the furosemide was found to be easier to administer to patients in increasing doses without these side-effects.[4]

Notes and References

  1. SANABRIA A . Ultrastructural changes produced in the rat kidney by a mercurial diuretic (meralluride) . Br J Pharmacol Chemother . 20 . 2. 352–61 . April 1963 . 13976179 . 1703643 . 10.1111/j.1476-5381.1963.tb01474.x.
  2. Kunin . Calvin A. . September 10, 1976 . Effect of organic mercurials and sulfhydryl compounds on the urease activity of Proteus: inhibition by urine and ascorbic acid . Antimicrob Agents Chemother . 10 . 3 . 503–506 . 10.1128/AAC.10.3.503 . 10828 . 429779 .
  3. Harris Jr. . William H. . January 1, 1953 . Mercuhydrin sensitivity, Report of a case . The Journal of Allergy and Clinical Immunology . 24 . 1 . 73–77 . 10.1016/0021-8707(53)90063-X . 13022218 . May 26, 2022.
  4. Luisada . A.A. . Madoery . R. . Levey . S. . Action of Certain Diuretics in Pulmonary Edema; An Experimental Study . Japanese Heart Journal . 1967 . 8 . 6 . 743–744 . 10.1536/ihj.8.743 . 5300580 . 32551048 . May 26, 2022. free .

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