Meprin A Explained

Meprin A
Ec Number:	3.4.24.18
Cas Number:	148938-24-3
Go Code:	0017090

Meprin A (endopeptidase-2, meprin-a, meprin, N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA-peptide hydrolase, PPH) is an enzyme that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.^[1] This metalloprotease can be associated with inflammatory responses.^[2] It can be found in the extracellular space where it can also form complex structures by joining its monomers together.

Meprin A is a dimer composed of the products transcribed from the following two genes:

Notes and References

1. Sterchi EE, Stöcker W, Bond JS . Meprins, membrane-bound and secreted astacin metalloproteinases . Molecular Aspects of Medicine . 29 . 5 . 309–28 . October 2008 . 18783725 . 2650038 . 10.1016/j.mam.2008.08.002 .
2. Prox J, Arnold P, Becker-Pauly C . Meprin α and meprin β: procollagen proteinases in health and disease. . Matrix Biology . May 2015 . 44 . 7–13 . 10.1016/j.matbio.2015.01.010 . 25617491 . free .