| Mendefera | |
| Mapsize: | 200px |
| Mapsize1: | 150px |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Name1: | Debub |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Mendefera |
| Unit Pref: | Metric |
| Timezone: | GMT +3 |
| Utc Offset: | +3 |
Mendefera Subregion is a subregion in the Debub (Southern) region (Zoba Debub) of Eritrea. Its capital lies at Mendefera.