| Honorific-Prefix: | Her Excellency |
| Men Sam An | |
| Honorific-Suffix: | MP |
| Office2: | Minister of National Assembly–Senate Relations and Inspection |
| Term Start2: | 16 July 2004 |
| Primeminister2: | Hun Sen |
| Term End2: | 22 August 2023 |
| Successor2: | Huot Hak |
| Term Start3: | 14 June 1993 |
| Office1: | Deputy Prime Minister of Cambodia |
| Term Start1: | 25 September 2008 |
| Term End1: | 22 August 2023 |
| Primeminister1: | Hun Sen |
| Office: | Vice President of the Cambodian People's Party |
| Term Start: | 24 December 2021 |
| Predecessor: | Hun Sen |
| President: | Hun Sen |
| Alongside: | Say Chhum, Sar Kheng and Tea Banh |
| Birth Date: | 15 August 1953 |
| Birth Place: | Sambour, Kratié, Cambodia, French Indochina |
| Party: | Cambodian People's Party |
| Nationality: | Cambodian |
| Allegiance: |  Cambodia |
| Branch: | Royal Cambodian Army |
| Serviceyears: | 1970–present[1] |
| Battles: | Cambodian Civil War |
Men Sam An (Central Khmer: ម៉ែន សំអន, UNGEGN: in Central Khmer pronounced as /maen sɑmʔɑːn/; born 15 August 1953) is a Cambodian politician. She belongs to the Cambodian People's Party and was elected to represent Svay Rieng Province in the National Assembly in 2003.[2]
As of 2009, she serves as permanent Deputy Prime Minister of Cambodia.[3] She is the first female deputy prime minister and four-star general.[1] She joined the army in 1970 during the US-backed Khmer Republic era, beginning her career as military nurse.