Membrane Pro-X carboxypeptidase explained

Membrane Pro-Xaa carboxypeptidase
Ec Number:3.4.17.16
Cas Number:9075-64-3

Membrane Pro-Xaa carboxypeptidase (carboxypeptidase P, microsomal carboxypeptidase) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction

Release of a C-terminal residue other than proline, by preferential cleavage of a prolyl bond

This is one of the renal brush border exopeptidases

Notes and References

  1. Dehm P, Nordwig A . The cleavage of prolyl peptides by kidney peptidases. Isolation of a microsomal carboxypeptidase from swine kidney . European Journal of Biochemistry . 17 . 2 . 372–7 . December 1970 . 5500406 . 10.1111/j.1432-1033.1970.tb01175.x . free .
  2. Booth AG, Hubbard LM, Kenny AJ . Proteins of the kidney microvillar membrane. Immunoelectrophoretic analysis of the membrane hydrolases: identification and resolution of the detergent- and proteinase-solubilized forms . The Biochemical Journal . 179 . 2 . 397–405 . May 1979 . 486090 . 1186637 . 10.1042/bj1790397 .
  3. Hedeager-Sørensen S, Kenny AJ . Proteins of the kidney microvillar membrane. Purification and properties of carboxypeptidase P from pig kidneys . The Biochemical Journal . 229 . 1 . 251–7 . July 1985 . 4038259 . 1145174 . 10.1042/bj2290251 .

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