| Melvin Spence | |
| State Delegate: | Virginia |
| District: | 38th |
| Term Start: | January 13, 1982 |
| Term End: | January 12, 1983 |
| Alongside: | Buster O'Brien, Owen Pickett, Glenn McClanan, and Billy O'Brien |
| Preceded: | Frederick H. Creekmore Tom Forehand |
| Succeeded: | Nora Anderson Squyres |
| Birthname: | Melvin Merritt Spence |
| Birth Date: | 9 May 1927 |
| Birth Place: | Norfolk, Virginia, U.S. |
| Party: | Republican |
| Spouse: | Betsy Winesett |
| Alma Mater: | Virginia Tech (BS) |
| Allegiance: | United States |
| Branch: | United States Navy |
| Serviceyears: | 1945 |
| Battles: | World War II |
Melvin Merritt Spence (May 9, 1927 – June 28, 2014) was an American politician who served as a member of the Virginia House of Delegates from 1982 to 1983.[1] Elected in 1981, he had to run for reelection the next year after a three-judge panel of the United States District Court for the Eastern District of Virginia found the state's multi-member districts to violated the equal protection clause. He was defeated in the newly-drawn 81st district by Owen B. Pickett.