| Melrose | |
| Settlement Type: | Unincorporated community |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Louisiana |
| Subdivision Type2: | Parish |
| Subdivision Name2: | Natchitoches |
| Pushpin Map: | Louisiana#USA |
| Pushpin Map Caption: | Location of Melrose in Louisiana |
| Coordinates: | 31.5989°N -92.9672°W |
| Elevation Ft: | 108 |
| Population Density Km2: | auto |
| Timezone1: | CST |
| Utc Offset1: | -6 |
| Timezone1 Dst: | CDT |
| Utc Offset1 Dst: | -5 |
| Postal Code Type: | ZIP code |
| Postal Code: | 71452[1] |
| Area Code: | 318 |
Melrose is an unincorporated community in Natchitoches Parish, Louisiana, United States, including the Melrose Plantation and surrounding area, on Louisiana Highway 119. In addition to the historic plantation, the Cane River Creole National Historical Park and Heritage Area encompass the Melrose area.
Melrose is part of the Natchitoches Micropolitan Statistical Area.