| Melpignano | |
| Address: | Melpignano, Province of Lecce, Apulia |
| Country: | Italy |
| Line: | Lecce-Otranto railway |
| Coordinates: | 40.1479°N 18.2772°W |
| Opened: | 1922 |
| Platforms: | 1 |
| Owned: | Ferrovie del Sud Est |
| Operator: | Ferrovie del Sud Est |
| Map Type: | Italy Apulia#Italy South#Italy |
Melpignano railway station is a railway station in Melpignano, Italy. The station is located on the Lecce-Otranto railway. The train services and the railway infrastructure are operated by Ferrovie del Sud Est.
The station is served by the following service:[1]