| Melissano | |
| Official Name: | Comune di Melissano |
| Shield Alt: | Coat of arms |
| Pushpin Label Position: | left |
| Coordinates: | 39.9667°N 26°W |
| Province: | Lecce (LE) |
| Mayor: | Roberto Falconieri |
| Area Total Km2: | 12 |
| Population Footnotes: | [1] |
| Population Total: | 7495 |
| Population As Of: | 31 December 2004 |
| Population Demonym: | Melissanesi |
| Elevation M: | 59 |
| Saint: | St. Anthony of Padua |
| Day: | June 13 |
| Postal Code: | 73040 |
| Area Code: | 0833 |
Melissano (Salentino: Sicilian: Milissanu;) is a town and comune in the province of Lecce, part of the Apulia region of south-east Italy.