| Consort: | yes |
| Melisende of Jerusalem | |
| Succession: | Princess of Antioch |
| Reign: | 1218-1233 |
| Spouse: | Bohemond IV of Antioch |
| House: | House of Lusignan |
| Father: | Aimery of Jerusalem |
| Mother: | Isabella I of Jerusalem |
| Issue: | Mary of Antioch |
| Birth Date: | 1200 |
| Birth Place: | Holy Land |
| Death Date: | after 1249 |
Melisende of Cyprus (1200 Holy Land- after 1249), was the youngest daughter of Queen Isabella I of Jerusalem by her fourth and last marriage to King Aimery of Cyprus. She had a sister Sibylla of Lusignan, a younger brother, Amalric who died as a young child. By her mother's previous marriages, Melisende had three half-sisters, Maria of Montferrat, who succeeded their mother as queen of Jerusalem on 5 April 1205; Alice of Champagne, and Philippa of Champagne.
In January 1218, Melisande married Prince Bohemond IV of Antioch. The marriage produced three daughters:
Melisende protested the succession of her nephew King Henry I of Cyprus as regent of Jerusalem on the death of her half-sister Alice in 1246. Alice had been regent of Jerusalem for Conrad IV of Germany.
She died sometime after 1249. Upon the childless death of her only surviving daughter, Marie sometime after December 1307, the line of Melisende became extinct.