Melike Lakadamyali Explained

Melike Lakadamyali
Nationality:Cypriot
Fields:Super-Resolution Microscopy
Single Molecule Biophysics
Thesis Title:Real-time Imaging of Viral Infection and Intracellular Transport in Live Cells
Thesis Year:2006
Academic Advisors:Xiaowei Zhuang
Jeff Lichtman
Known For:Super-Resolution Microscopy
Single Molecule Biophysics
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Melike Lakadamyali is a Cypriot physicist and an Associate Professor of Physiology and of Cell and Developmental Biology (secondary) at the University of Pennsylvania in Philadelphia, renowned for her work in super-resolution microscopy and Single Molecule Biophysics. She is the Group Leader of the Lakadamyali Lab.[1]

Education

From 1997 to 2001, Lakadamyali studied Physics at the University of Texas at Austin, USA. During the end of her university time, she gained some practical experience by working in the labs of Prof. Ken Shih and Prof. Josef A. Käs. From 2001 to 2006, she earned her Ph.D. in Physics at Harvard University, Cambridge, MA, USA, advised by Prof Xiaowei Zhuang,[2] [3] [4] focusing on the visualization of viral infection and intracellular transport in live cells.[5] [6] [7]

Career and research

For her postgraduate work, Lakadamyali worked as a postdoctoral researcher under Prof Jeff Lichtman at the Center forBrain Science at Harvard University, MA, USA.[8] Between 2010 and 2016, Lakadamyali was a Group Leader at ICFO - The Institute of Photonic Sciences in Barcelona, Spain, holding a Junior (2010-2015) and Senior (2015-2016) Group Leader position, respectively. Her group's superresolution microscopy study investigating the genome gained widespread attention. It reveals that our genome needs to be regularly packaged and links these packaging differences to stem cell state.[9] [10] [11]

In 2017, Lakadamyali returned to the United States to work as an Assistant Professor of Physiology and of Cell and Developmental Biology (secondary) at the University of Pennsylvania in Philadelphia.

In 2020, Lakadamyali was promoted to Associate Professor of Physiology and in 2024 she was promoted to Full Professor.

Lakadamyali's area of research is focused on examining biology at the level of its macromolecular machines. She aims to obtain a quantitative and biophysical comprehension of how these machines propel critical cell biological processes.[12] [13] [14] Hence, she is also involved in designing sophisticated microscopy techniques that strive to surmount the current limitations of existing methods, thereby enabling them to observe the macromolecular machinery of the cell in motion with superior spatiotemporal resolution.[15] [16] [17]

Lakadamyali is a well-known microscopist and biophysicist. Hence, she is frequently invited to speak at workshops[18] [19] and conferences[20] [21] [22] in the field.

Since 2019, Lakadamyali has been a Reviewing Editor (Cell Biology) at eLife.[23]

Awards and honours

Notes and References

  1. Web site: Lakadamyali Lab . Lakadamyali Lab . 2023-09-04.
  2. Web site: Curriculum Vitae: Melike Lakadamyali . 4 September 2023 . static1.squarespace.com.
  3. Web site: Melike Lakadamyali . 4 September 2023 . AcademiaNet.
  4. Web site: Cell scientist to watch − Melike Lakadamyali | Journal of Cell Science | The Company of Biologists . Journals.biologists.com . 2017-05-15 . 2023-09-04.
  5. Lakadamyali . Melike . Rust . Michael J. . Babcock . Hazen P. . Zhuang . Xiaowei . 2003-08-05 . Visualizing infection of individual influenza viruses . Proceedings of the National Academy of Sciences . en . 100 . 16 . 9280–9285 . 10.1073/pnas.0832269100 . free . 0027-8424 . 170909 . 12883000. 2003PNAS..100.9280L .
  6. Single-Particle Virus Tracking . Cshprotocols.cshlp.org . 2011-09-01 . 21880810 . 2023-09-04 . Rust . M. J. . Lakadamyali . M. . Brandenburg . B. . Zhuang . X. . Cold Spring Harbor Protocols . 2011 . 9 . pdb.prot065631 . 10.1101/pdb.prot065631 .
  7. Single-Virus Tracking in Live Cells . Cshprotocols.cshlp.org . 2011-09-01 . 21880811 . 2023-09-04 . Rust . M. J. . Lakadamyali . M. . Brandenburg . B. . Zhuang . X. . Cold Spring Harbor Protocols . 2011 . 9 . pdb.top065623 . 10.1101/pdb.top065623 .
  8. 3D Multicolor Super-Resolution Imaging Offers Improved Accuracy in Neuron Tracing | PLOS ONE . Journals.plos.org . 2012-01-24 . 10.1371/journal.pone.0030826 . free . 22292051 . Lakadamyali . M. . Babcock . H. . Bates . M. . Zhuang . X. . Lichtman . J. . PLOS ONE . 7 . 1 . e30826 . 3265519 .
  9. Ricci . Maria Aurelia . Manzo . Carlo . García-Parajo . María Filomena . Lakadamyali . Melike . Pia Cosma . Maria . 12 March 2015 . Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo . . 160 . 6 . 1145–1158 . 10.1016/j.cell.2015.01.054. free . 25768910 . 10803/298724 . free .
  10. Web site: Nucleosome clutches / Cell, March 12, 2015 (Vol. 160, Issue 6) . YouTube . 2023-09-04.
  11. Web site: Centre for Genomic Regulation Website . Crg.eu . 2015-03-12 . 2023-09-04.
  12. Web site: Super resolution microscopy reveals how elongating RNA polymerase II and nascent RNA interact with nucleosome clutches | Nucleic Acids Research | Oxford Academic . Academic.oup.com . 2023-09-04.
  13. Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation . 2021. 10.1016/j.celrep.2020.108614 . Gómez-García . Pablo Aurelio . Portillo-Ledesma . Stephanie . Neguembor . Maria Victoria . Pesaresi . Martina . Oweis . Walaa . Rohrlich . Talia . Wieser . Stefan . Meshorer . Eran . Schlick . Tamar . Cosma . Maria Pia . Lakadamyali . Melike . Cell Reports . 34 . 2 . 33440158 . 7842188 .
  14. Lakadamyali . Melike . Cosma . Maria Pia . 2020. Visualizing the genome in high resolution challenges our textbook understanding . Nature Methods . en . 17 . 4 . 371–379 . 10.1038/s41592-020-0758-3 . 32123395 . 1548-7105. 10230/43808 . 211729851 . free .
  15. Web site: Melike Lakadamyali | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of Pennsylvania . Med.upenn.edu . 2023-09-04.
  16. Technological advances in super-resolution microscopy to study cellular processes . 2022-01-20 . 10.1016/j.molcel.2021.12.022 . Bond . Charles . Santiago-Ruiz . Adriana N. . Tang . Qing . Lakadamyali . Melike . Molecular Cell . 82 . 2 . 315–332 . 35063099 . 8852216 .
  17. Hugelier . Siewert . Colosi . P.L. . Lakadamyali . Melike . 2023-05-09 . Quantitative Single-Molecule Localization Microscopy . Annual Review of Biophysics . en . 52 . 1 . 139–160 . 10.1146/annurev-biophys-111622-091212 . 1936-122X. free . 37159293 . 11268362 .
  18. Web site: In situ structural biology: from cryo-EM to multi-scale modelling – Course and Conference Office . Embl.org . 2023-09-04.
  19. Web site: Home . 22nd Single Molecule Workshop . PicoQuant . 2023-09-04.
  20. Web site: JCS2023: Imaging Cell Dynamics - The Company of Biologists . Biologists.com . 2023-09-04.
  21. Web site: Seeing is Believing – Imaging the Molecular Processes of Life – Course and Conference Office . Embl.org . 2019-10-12 . 2023-09-04.
  22. Web site: Genome Organization & Nuclear Function 2022 CSHL . 2023-09-04 . meetings.cshl.edu.
  23. Web site: Editors for Cell Biology . 2023-09-04 . eLife . en.
  24. Web site: EMBO Young Investigator Program . 2023-09-04 . ICFO . en-US.
  25. Web site: Physical Sciences and Engineering - List of Principal Investigators . 4 September 2023 . erc.europa.eu.
  26. Web site: On the move: Motor-cargo and motor-microtubule interactions studied with quantitative, high spatio-temporal resolution microscopy in vivo . 4 September 2023 . CORDIS.
  27. Web site: ERC Starting Grant Awarded to Prof. Melike Lakadamyali . 2023-09-04 . ICFO . en-US.
  28. Marx . Vivien . 2017-08-01 . Melike Lakadamyali . Nature Methods . en . 14 . 8 . 755 . 10.1038/nmeth.4369 . 1548-7105. free .

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