Melevodopa Explained

Melevodopa, also known as levodopa methyl ester (LDME) and sold under the brand name Levomet, is a dopaminergic agent. It is the methyl ester of levodopa.[1] It is used in oral tablet form as an effervescent prodrug with 250times the water solubility of tablet levodopa.[2] [3] In combination with carbidopa, as melevodopa/carbidopa (brand name Sirio), it is approved for use in the treatment of Parkinson's disease.[4] [5]

See also

Notes and References

  1. Book: Buckingham J, Baggaley K, Roberts A, Szabo L . Dictionary of Alkaloids with CD-ROM . CRC Press . 2010 . 978-1-4200-7770-4 . 28 September 2024 . 103.
  2. Hickey P, Stacy M . Available and emerging treatments for Parkinson's disease: a review . Drug Design, Development and Therapy . 5 . 241–254 . 2011 . 21607020 . 3096539 . 10.2147/DDDT.S11836 . free .
  3. Stocchi F, Marconi S . Factors associated with motor fluctuations and dyskinesia in Parkinson Disease: potential role of a new melevodopa plus carbidopa formulation (Sirio) . Clin Neuropharmacol . 33 . 4 . 198–203 . July 2010 . 20414107 . 10.1097/WNF.0b013e3181de8924 .
  4. Web site: Melevodopa/carbidopa . AdisInsight . Springer Nature Switzerland AG . 23 September 2021 . 27 September 2024.
  5. Web site: Melevodopa: Uses, Interactions, Mechanism of Action . DrugBank Online . 1 April 2015 . 27 September 2024.

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