Melanie Brinkmann Explained

Melanie Brinkmann is a German virologist. Until 2019 she was probably best known in connection with her work on the Cytomegalovirus. During 2020 she emerged as a much consulted expert-pundit for media commentators keen to discuss the COVID-19 pandemic. Brinkmann took a robust public position in the campaign against pandemic misinformation: she described the so-called "virus of false information" as "more deadly than the [COVID-19] virus itself".[1] [2] [3] [4] [5]

Early life and education

Melanie Margarete Brinkmann was born at Neustadt am Rübenberge, a town near Hanover, and attended school in nearby Garbsen. In 1993 she enrolled at the University of Hanover where for a year she studied Anglistics and Sociology. In 1994 she transferred to Göttingen, emerging two years later with a first degree in Biology.[6] Following a formal 'very good' (German: sehr gut) commendation in recognition of her exam grades Brinkmann moved on again, this time to Berlin, still studying biology.[4] However, it was from the University of Hanover that in 2004 she received her doctorate, for which she was supervised by Thomas F. Schulz. Her dissertation concerned the "Functional properties of proteins encoded by the K15 gene of the Kaposi's sarcoma-associated herpesvirus".[7] [8] As well as the doctorate, this work earned her a "summa cum laude" commendation[1] and the doctorates prize awarded by the Hannover Medical School.[4] In 2007 she received a postdoctoral research prize for Virology from the Berlin-based Robert Koch Foundation.[1]

Career

Supported by a research grant from the Bonn-based DFG, between 2006 and 2010 Brinkmann worked as a postdoctoral researcher with Hidde Ploegh at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts.[1] Her research focus was on Toll-like receptors (TLRs).[8]

In July 2010 Brinkmann took on the leadership of the "Immunotherapy Successor Group" ("Nachwuchsgruppe: Virale Immunmodulation") at the Helmholtz Centre for Infection Research (HZI) in Braunschweig. She has since been involved in several virology and immunology research projects backed by the DFG.[9] The work she undertook between 2005 and 2008 in Massachusetts on TLRs was one of these: the project had as its objective the investigation of Herpesvirales immune escape.[10] Since 2010 she has been co-leader of the DFG project on Modulation of the Immune Response through the Gammaherpesvirinae-linked Kaposi's sarcoma, associated with the Herpesviridae and the Murines Herpesvirus 68 (BO3).[11]

Since 2018 Brinkmann has held a Level W2 professorship in Virus Genetics at the Genetics Institute of the "Technical University of Braunschweig" (TUB),[12] in which she oversees the "Infections and Active Elements" ("Infektionen und Wirkstoffe") research speciality.[8]

Media profile

During the spread of the COVID-19 pandemic Brinkmann became a frequent media presence, principally in Germany. In May 2020 she was co-organiser and a co-signatory, with Christian Drosten of the Charité, of an open letter from 100 doctors, nurses and health experts calling for stronger action to be taken by providers of media platforms/services against pandemic misinformation.[13] [14] Billed, by this time, as "Germany's best known virologist", she shared these concerns in a television interview on 7 May 2020, insisting on the importance to virologists that infected people should not use false information as the basis for decisions that could imperil their lives or the lives of others: "We must ensure that information that has not yet been adequately evaluated by experts does not become widely disseminated".[3]

Other activities

Recognition

In 2016 Brinkmann received the Science Award - donated by Biomol GmbH of Hamburg - from the Hanover-based Signal transduction Society.[16]

Notes and References

  1. Web site: Melanie M. Brinkmann. Preis für Postdoktorandinnen und Postdoktoranden für Virologie 2007 (Ckick on "Laudatio" and "Lebenslauf". Robert-Koch-Stiftung e.V., Berlin. 19 December 2020.
  2. Web site: Antrittsvorlesung von Prof. Dr. Melanie M. Brinkmann .... zur Person . . Die faszinierende Welt der Viren . 19 December 2020.
  3. Web site: Gegen das Virus der Falschinformation . 7 May 2020 . Ärzte und Virologen .... "Tödlicher als das Virus selber". Marcel Kolvenbach . Norddeutscher Rundfunk, Hamburg . 19 December 2020.
  4. Web site: Viral Immune Modulation .... Prof Dr Melanie Brinkmann . Helmholtz-Zentrum für Infektionsforschung GmbH, Braunschweig . 19 December 2020.
  5. Web site: "Im Laufe eines Sommers wird das nicht klappen" . 15 June 2020. Viele hoffen darauf, dass die Lockerungen der Corona-Maßnahmen zu mehr Immunität gegen das Virus führen. Die Virologin Melanie Brinkmann dämpft die Hoffnungen. . Janne Kieselbach . Der Spiegel (online) . 19 December 2020.
  6. Web site: Melanie M. Brinkmann. Preis für Postdoktorandinnen und Postdoktoranden für Virologie 2007 (Ckick on "Laudatio" and "Lebenslauf". Robert-Koch-Stiftung e.V., Berlin. 19 December 2020.
  7. Web site: Functional properties of proteins encoded by the K15 gene of the Kaposi's sarcoma-associated herpesvirus (KSHV) . Melanie Brinkmann . 2004 . To read the full-text of this research, you can request a copy directly from the author. . 19 December 2020.
  8. Web site: Antrittsvorlesung "Die faszinierende Welt der Viren" . Melanie Brinkmann studierte Biologie in Göttingen ... (biographical note on Melanie Brinkmann in connection with a public lecture she delivered in 2019). Technische Universität Braunschweig. 6 November 2019. 19 December 2020.
  9. Web site: Detailseite: Professorin Dr. Melanie Brinkmann . click on [Projekte] . Deutsche Forschungsgemeinschaft (DFG), Bonn . 21 December 2020.
  10. Web site: Detailseite: Toll-like Rezeptoren: Ziele der herpesviralen Immun-Evasion? / Goals of Herpes Virus Immune Evasion? . Herpesviren etablieren lebenslange, persistierende Infektionen und haben während Jahrzehntausenden der Koevolution mit ihren Wirten Mechanismen hervorgebracht, um der Eliminierung durch das Wirtsimmunsystem zu entgehen. Für die Existenz von Strategien der Herpesviren, die durch Toll-like Rezeptoren (TLRs)-vermittelte angeborene Immunantwort zu modulieren, gibt es folgende Indizien ..... . 2008 . Deutsche Forschungsgemeinschaft (DFG), Bonn . 21 December 2020.
  11. Web site: Detailseite: Modulation der Immunantwort durch die Gammaherpesviren Kaposi Sarkom-assoziiertes Herpesvirus und Murines Herpesvirus 68 (B03) . Das Tumorvirus Kaposi Sarkom-assoziiertes Herpesvirus (KSHV) ist die Ursache zahlreicher Krankheiten, unter anderem des Kaposi Sarkoms (KS), der häufigsten Krebsart bei HIV-infizierten Individuen. Die Infektion mit KSHV wird vom Immunsystem erkannt, jedoch ..... . 2008 . Deutsche Forschungsgemeinschaft (DFG), Bonn . 21 December 2020.
  12. Web site: .... rof. Dr. rer. nat. Melanie M. Brinkmann – W2 - Professorin an der TU Braunschweig . Personalia . . 21 December 2020.
  13. Web site: Offener Brief - Ärzte bekämpfen Fake-News . Tausende Menschen bekommen täglich falsche Informationen rund um das Coronavirus zu sehen. Nun wenden sich Ärzte und Experten, darunter Melanie Brinkmann und Christian Drosten, in einem offenen Brief an die Betreiber der Plattformen. Sie fordern zwei Schritte.. 11 May 2020. Die Mittelländische Zeitung (online) FR. 21 December 2020.
  14. Web site: Personalmangel erschwert Kampf gegen Corona-Falschinformationen. Die großen Netzwerke werden mit falschen und teils gefährlichen Corona-Inhalten geflutet. Doch die Plattformen haben ein Problem: Ihre Moderatoren sind im Homeoffice und arbeiten nur eingeschränkt.. Marcel Rosenbach. 8 May 2020. Der Spiegel (online). 21 December 2020.
  15. https://www.hpi-hamburg.de/en/the-hpi/structure-and-staff/scientific-advisory-board/ Scientific Advisory Board
  16. Web site: STS-Science Awards . The murine cytomegalovirus protein M35 is a novel negative regulator of the type I interferon response. . Gesellschaft für Signaltransduktion e.V., Medical School Hannover . 21 December 2020.

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