| Official Name: | Melakhino |
| Native Name: | Мелахино |
| Native Name Lang: | ru |
| Settlement Type: | Selo |
| Pushpin Map: | Russia Voronezh Oblast#Russia |
| Subdivision Type: | Country |
| Subdivision Name: | Russia |
| Subdivision Type1: | Region |
| Subdivision Name1: | Voronezh Oblast |
| Subdivision Type2: | County |
| Subdivision Type3: | District |
| Subdivision Name3: | Liskinsky District |
| Subdivision Type4: | Municipality |
| Utc Offset1: | +3:00 |
| Coordinates: | 50.85°N 59°W[1] |
Melakhino (Russian: links=no|Мелахино) is a rural locality (a selo) in Kovalyovskoye Rural Settlement, Liskinsky District, Voronezh Oblast, Russia. The population was 61 as of 2010.[2] There are 2 streets.[3]
Melakhino is located 35 km southwest of Liski (the district's administrative centre) by road. Misevo is the nearest rural locality.[4]