| Grote 1-MeiPrijs | |
| Date: | 1 May |
| Region: | Hoboken, Flanders, Belgium |
| Localnames: | 1-MeiPrijs |
| Discipline: | Road |
| Competition: | UCI Europe Tour |
| Type: | One-day race |
| Number: | 88 |
| Last: | 2015 |
| Mostwins: | 3 riders (3 wins each) |
The Grote 1-MeiPrijs (also named Ereprijs Victor De Bruyne) was a European single-day cycle race held in the Belgian region of Flanders, around Hoboken. From 2005, the race was organized as a 1.2 event on the UCI Europe Tour. The race was downgraded to a national event in 2014 and was not held after 2015.