SERPINB7 explained

Serpin B7 is a protein that in humans is encoded by the SERPINB7 gene.^[1]

See also

• Serpin

Further reading

• Tsujimoto M, Tsuruoka N, Ishida N, etal . Purification, cDNA cloning, and characterization of a new serpin with megakaryocyte maturation activity. . J. Biol. Chem. . 272 . 24 . 15373–80 . 1997 . 9182567 . 10.1074/jbc.272.24.15373 . free .
• Miyata T, Nangaku M, Suzuki D, etal . A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy. . J. Clin. Invest. . 102 . 4 . 828–36 . 1998 . 9710452 . 10.1172/JCI2450 . 508946 .
• Inagi R, Miyata T, Suzuki D, etal . Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy. . Biochem. Biophys. Res. Commun. . 286 . 5 . 1098–106 . 2001 . 11527413 . 10.1006/bbrc.2001.5509 .
• Inagi R, Miyata T, Imasawa T, etal . Mesangial cell-predominant gene, megsin. . Nephrol. Dial. Transplant. . 17 Suppl 9 . 90009. 32–3 . 2003 . 12386281 . 10.1093/ndt/17.suppl_9.32. free .
• Inagi R, Miyata T, Nangaku M, etal . Transcriptional regulation of a mesangium-predominant gene, megsin. . J. Am. Soc. Nephrol. . 13 . 11 . 2715–22 . 2003 . 12397041 . 10.1097/01.ASN.0000033507.32175.FA . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Li YJ, Du Y, Li CX, etal . Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene. . J. Am. Soc. Nephrol. . 15 . 7 . 1739–43 . 2004 . 15213261 . 10.1097/01.ASN.0000130858.00688.46 . free .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Inagi R, Nangaku M, Usuda N, etal . Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin. . J. Am. Soc. Nephrol. . 16 . 5 . 1339–49 . 2005 . 15788472 . 10.1681/ASN.2004070600 . free .
• Xia Y, Li Y, Du Y, etal . Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy. . Nephrol. Dial. Transplant. . 21 . 6 . 1570–4 . 2006 . 16431886 . 10.1093/ndt/gfk096 .
• Xia YF, Huang S, Li X, etal . A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population. . Clin. Nephrol. . 65 . 3 . 153–9 . 2006 . 16550745 . 10.5414/cnp65153.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.012

Notes and References

1. Web site: Entrez Gene: SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7.