Medium-chain acyl-CoA dehydrogenase explained

Medium-chain acyl-CoA dehydrogenase
Ec Number:	1.3.8.7
Width:	270

Medium-chain acyl-CoA dehydrogenase (fatty acyl coenzyme A dehydrogenase (ambiguous), acyl coenzyme A dehydrogenase (ambiguous), acyl dehydrogenase (ambiguous), fatty-acyl-CoA dehydrogenase (ambiguous), acyl CoA dehydrogenase (ambiguous), general acyl CoA dehydrogenase (ambiguous), medium-chain acyl-coenzyme A dehydrogenase, acyl-CoA:(acceptor) 2,3-oxidoreductase (ambiguous), ACADM (gene name).) is an enzyme with systematic name medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase.^{[1] [2] [3] [4] [5] [6] [7] [8]} This enzyme catalyses the following chemical reaction

\rightleftharpoons a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein

This enzyme contains FAD as prosthetic group and participates in fatty acid metabolism and PPAR signaling pathway.^[9]

Notes and References

1. Crane FL, Hauge JG, Beinert H . Flavoproteins involved in the first oxidative step of the fatty acid cycle . Biochimica et Biophysica Acta . 17 . 2 . 292–4 . June 1955 . 13239683 . 10.1016/0006-3002(55)90374-7 .
2. Crane FL, Mii S, Hauge JG, Green DE, Beinert H . On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. I. The general fatty acyl coenzyme A dehydrogenase . The Journal of Biological Chemistry . 218 . 2 . 701–6 . February 1956 . 10.1016/S0021-9258(18)65836-3 . 13295224 . free .
3. Book: Acyl coenzyme A dehydrogenase . The Enzymes . Beinert, H. . 1963 . 7 . 447–466 . Boyer, P.D. . Lardy, H. . Myrbäck, K. . 2nd . Academic Press . New York .
4. Ikeda Y, Okamura-Ikeda K, Tanaka K . Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme . The Journal of Biological Chemistry . 260 . 2 . 1311–25 . January 1985 . 10.1016/S0021-9258(20)71245-7 . 3968063 . free .
5. Thorpe C, Kim JJ . Structure and mechanism of action of the acyl-CoA dehydrogenases . FASEB Journal . 9 . 9 . 718–25 . June 1995 . 7601336 . 10.1096/fasebj.9.9.7601336. free . 42549744 .
6. Kim JJ, Wang M, Paschke R . Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate . Proceedings of the National Academy of Sciences of the United States of America . 90 . 16 . 7523–7 . August 1993 . 8356049 . 47174 . 10.1073/pnas.90.16.7523 . 1993PNAS...90.7523K . free .
7. Peterson KL, Sergienko EE, Wu Y, Kumar NR, Strauss AW, Oleson AE, Muhonen WW, Shabb JB, Srivastava DK . Recombinant human liver medium-chain acyl-CoA dehydrogenase: purification, characterization, and the mechanism of interactions with functionally diverse C8-CoA molecules . Biochemistry . 34 . 45 . 14942–53 . November 1995 . 7578106 . 10.1021/bi00045a039 .
8. Toogood HS, van Thiel A, Basran J, Sutcliffe MJ, Scrutton NS, Leys D . Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex . The Journal of Biological Chemistry . 279 . 31 . 32904–12 . July 2004 . 15159392 . 10.1074/jbc.M404884200 . free .
9. Ezzeddini R, Taghikhani M, Salek Farrokhi A, Somi MH, Samadi N, Esfahani A, Rasaee, MJ . Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and its related clinical significance . Journal of Physiology and Biochemistry . 77 . 2 . 249–260 . May 2021 . 33730333 . 10.1007/s13105-021-00791-3 . 232300877 .