| Mduduzi Mdantsane | |
| Birth Date: | 13 December 1994 |
| Birth Place: | Leandra, South Africa |
| Height: | 1.67 m |
| Position: | Midfielder |
| Currentclub: | Kaizer Chiefs |
| Clubnumber: | 3 |
| Years1: | 2017–2019 |
| Clubs1: | Baroka |
| Caps1: | 72 |
| Goals1: | 8 |
| Years2: | 2019–2023 |
| Clubs2: | Cape Town City |
| Caps2: | 94 |
| Goals2: | 20 |
| Years3: | 2023— |
| Clubs3: | Kaizer Chiefs |
| Caps3: | 13 |
| Goals3: | 0 |
| Nationalyears1: | 2021– |
| Nationalteam1: | South Africa |
| Nationalcaps1: | 1 |
| Nationalgoals1: | 0 |
| Club-Update: | 30 June 2024 |
| Nationalteam-Update: | 11 November 2021 |
Mduduzi Mdantsane (born 13 December 1994) is a South African soccer player who plays as a midfielder for South African Premier Division side Kaizer Chiefs FC.
He made his debut for South Africa national soccer team on 11 November 2021 in a World Cup qualifier against Zimbabwe.[1]