| Mduduzi Mdantsane | |
| Birth Date: | 13 December 1994 |
| Birth Place: | Leandra, South Africa |
| Height: | 1.67 m |
| Position: | Midfielder |
| Currentclub: | Kaizer Chiefs |
| Clubnumber: | 3 |
| Years1: | 2017–2019 |
| Clubs1: | Baroka |
| Caps1: | 72 |
| Goals1: | 8 |
| Years2: | 2019–2023 |
| Clubs2: | Cape Town City |
| Caps2: | 94 |
| Goals2: | 20 |
| Years3: | 2023— |
| Clubs3: | Kaizer Chiefs |
| Caps3: | 13 |
| Goals3: | 0 |
| Nationalyears1: | 2021– |
| Nationalteam1: | South Africa |
| Nationalcaps1: | 1 |
| Nationalgoals1: | 0 |
| Club-Update: | 30 June 2024 |
| Nationalteam-Update: | 11 November 2021 |
Mduduzi Mdantsane (born 13 December 1994) is a South African soccer player who plays as a midfielder for South African Premier Division side Kaizer Chiefs FC.
Mduduzi was born in Leandra on 13 December 1994.
He made his debut for South Africa national soccer team on 11 November 2021 in a World Cup qualifier against Zimbabwe.