| McDonald Run | |
| Name Other: | Tributary to Slippery Rock Creek |
| Map Size: | 300 |
| Pushpin Map: | Pennsylvania#USA |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of McDonald Run mouth |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Pennsylvania |
| Subdivision Type3: | County |
| Subdivision Name3: | Butler |
| Length: | 3.07miles[1] |
| Discharge1 Location: | Slippery Rock Creek |
| Discharge1 Avg: | 6.07cuft/s at mouth with Slippery Rock Creek[2] |
| Source1: | divide between McDonald Run and McMurray Run |
| Source1 Location: | Forestville, Pennsylvania[3] |
| Source1 Coordinates: | 41.1081°N -80.0111°W[4] |
| Source1 Elevation: | 1330feet |
| Mouth: | Slippery Rock Creek |
| Mouth Location: | about 1 mile south of Branchton, Pennsylvania |
| Mouth Coordinates: | 41.0608°N -79.9878°W |
| Mouth Elevation: | 1160feet |
| Progression: | Slippery Rock Creek → Connoquenessing Creek → Beaver River → Ohio River → Mississippi River → Gulf of Mexico |
| River System: | Beaver River |
| Tributaries Left: | unnamed tributaries |
| Tributaries Right: | unnamed tributaries |
McDonald Run is a 3.07miles long tributary to Slippery Rock Creek that rises near Forestville in Butler County, Pennsylvania and flows south to meet Slippery Rock Creek near Branchton.