McCune is an unincorporated community in Pike County, in the U.S. state of Missouri.
The community is on Missouri Route U just west of the intersection with US Route 61. Peno Creek flows past about a quarter mile to the west. Bowling Green is six miles to the southeast on Route 61.[1]
Variant names were "McCunes" and "McCune Station". A post office called McCunes Station was established in 1879, and remained in operation until 1920.[2] The community has the name of John and William McCune, pioneer citizens.[3]