| Mayo-Sava | |
| Settlement Type: | Department |
| Mapsize: | 300px |
| Pushpin Map: | Cameroon#Africa |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 300 |
| Subdivision Type: | Country |
| Subdivision Name: |  Cameroon |
| Subdivision Type1: | Province |
| Subdivision Name1: | Extreme-Nord Province |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Mora |
| Unit Pref: | Imperial |
| Area Total Km2: | 2736 |
| Population As Of: | 2005 |
| Population Total: | 348,890 |
| Population Blank1 Title: | Ethnicities |
| Timezone: | WAT |
| Utc Offset: | +1 |
| Coordinates: | 11.0733°N 14.1726°W |
Mayo-Sava is a department of Extreme-Nord Province in Cameroon. The department covers an area of 2,736 km and at the 2005 Census had a total population of 348,890.[1] The capital of the department is at Mora.
The department is divided administratively into 3 communes and in turn into villages.