| Official Name: | Mayhansse |
| Native Name: | ማይሓንሰ |
| Settlement Type: | Town |
| Pushpin Map: | Ethiopia |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location within Ethiopia |
| Coordinates: | 14.1245°N 37.8773°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Ethiopia |
| Subdivision Type1: | Region |
| Subdivision Type2: | Zone |
| Subdivision Name2: | Northwestern Zone |
| Subdivision Type3: | Woreda |
| Subdivision Name3: | Mayhansse |
| Elevation M: | 1124.712 |
| Population Total: | 8,000 |
| Population As Of: | 2020 |
| Timezone: | EAT |
| Utc Offset: | +3 |
Mayhansse(Ge'ez: ማይሓንሰ), is a town in Asgede district in the Tigray Region of Ethiopia located 60 km west of Shire in the highway to Dansha, Western zone Tigray. The town is the largest town in Asgede woreda (district) with population of 91,222 (as of 2020).