Mayfield Creek is a stream in Bollinger County in the U.S. state of Missouri. The stream is a tributary to the Little Whitewater Creek.[1] The community of Mayfield, Missouri lies approximately one mile to the northwest of the confluence on another small tributary to the Little Whitewater.[1]
Mayfield Creek bears the name of a local family of settlers; this family is also the namesake of Mayfield, Kentucky.[2]